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Clinical and Translational Nutrition
Session Type: Sponsored Satellite Program

The Scientific Evolution of Bioactives in Human Health, Current Challenges, and the Path Ahead Illuminated by AI Driven Science (Sponsored Satellite Program)

Sunday, July 23, 2023
12:00 PM – 1:30 PM ET
Location: Back Bay B-D

Sponsored by Brightseed

Learning Objectives

At the end of this activity, learners will be able to:
  • Share proposed framework for Bioactives Nomenclature and Definition, especially as it relates to bioactives identified through new technologies (AI)
  • Discuss degree and type of evidence required to substantiate health benefits and the role that mechanistic (MoA) data might play, as well as propose strategies to increase daily intake of bioactives (crop variety selection, fortification, supplements
  • Encourage the use of 'Food as Medicine' approach and highlight the most pressing target health areas for bioactives, specifically where the opportunities are most significant given the state of public health.

      • Chair(s)

    • Katie Stebbins, MS

      Executive Director
      Tufts University Food & Nutrition Innovation Institute
      Boston, Massachusetts, United States

      Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

      • Co-Chair(s)

    • SK

      Swati Kalgaonkar, PhD

      Director, Medical & Scientific Affairs
      Medical & Scientific Affairs
      Brightseed
      South San Francisco, California, United States

      Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

      • Speaker(s)

    • Jan-Willem Van Klinken, MD, PhD, MS, FACN (he/him/his)

      SVP Medical/Scientific/Regulatory Affairs
      Medical, Scientific & Regulatory Affairs
      Brightseed
      Chatham, New Jersey, United States

      Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

    • CK

      Christina Khoo, PhD (she/her/hers)

      Director
      Ocean Spray
      Lakeville, Massachusetts, United States

      Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

    • Mario Ferruzzi, PhD

      Professor and Section Chief
      Department of Food, Bioprocessing & Nutrition Sciences
      University of Arkansas for Medical Sciences
      Little Rock, Arkansas, United States

      Disclosure(s): Brightseed: Grant/Research Support (Ongoing)
      Cargill: Grant/Research Support (Ongoing)
      Chick-Fila: Advisory Committee/Board Member (Ongoing)
      Chlorox-Nutranext: Advisory Committee/Board Member (Terminated, December 31, 2022)
      Ekaterra: Consultant (Ongoing); Grant/Research Support (Ongoing)
      National Institutes of Health (NIH): Grant/Research Support (Ongoing)
      PepsiCo Incorporated: Grant/Research Support (Ongoing)
      Sensient Technologies: Executive Role (e.g. Board of Directors) (Ongoing); Stock Shareholder (excluding mutual funds) (Ongoing)
      University of Arkansas for Medical Sciences: Employee (Ongoing)
      US Tea Association: Speaker/Speaker's Bureau (Terminated, May 31, 2022)
      USAID: Grant/Research Support (Ongoing)
      USDA-ARS: Grant/Research Support (Ongoing)

    Disclosure(s):
    Katie Stebbins: No relevant financial relationship(s) with ineligible companies to disclose.
    Swati Kalgaonkar, PhD: No relevant financial relationship(s) with ineligible companies to disclose.
    Jan-Willem Van Klinken, MD, PhD, MS, FACN: No relevant financial relationship(s) with ineligible companies to disclose.
    Christina Khoo, PhD: No relevant financial relationship(s) with ineligible companies to disclose.
    Mario G. Ferruzzi, PhD: Brightseed: Grant/Research Support (Ongoing)
    Cargill: Grant/Research Support (Ongoing)
    Chick-Fila: Advisory Committee/Board Member (Ongoing)
    Chlorox-Nutranext: Advisory Committee/Board Member (Terminated, December 31, 2022)
    Ekaterra: Consultant (Ongoing); Grant/Research Support (Ongoing)
    National Institutes of Health (NIH): Grant/Research Support (Ongoing)
    PepsiCo Incorporated: Grant/Research Support (Ongoing)
    Sensient Technologies: Executive Role (e.g. Board of Directors) (Ongoing); Stock Shareholder (excluding mutual funds) (Ongoing)
    University of Arkansas for Medical Sciences: Employee (Ongoing)
    US Tea Association: Speaker/Speaker's Bureau (Terminated, May 31, 2022)
    USAID: Grant/Research Support (Ongoing)
    USDA-ARS: Grant/Research Support (Ongoing)

    The overall session theme is to bring awareness to the evolving role of bioactives in human health, current challenges that prevent a universal understanding of their dietary value, and steps that can be taken to raise awareness around the importance of their inclusion in the diet, either through food sources or with the use of supplements. The first speaker will cover past and recent advances in bioactives research, including the publication featuring the most recent guideline development on flavan-3-ols (Crowe-White et al. 2022). The second speaker will lay out current challenges, like a universally accepted definition, product application, and availability of adequate scientific data to support dietary recommendations. The final speaker will present the future of bioactives, including high throughput discoveries using AI driven science and the scientific requirements to stay abreast. A panel discussion will ensue, providing different angles on these topics, followed by an open Q&A session.

    Presentations:

    • 12:00 PM – 12:05 PM ET
      Introduction - The Scientific Evolution of the Role of Bioactives in Human Health, Their Current Challenges, and the Path Ahead Illuminated by AI Driven Science (Sponsored Satellite Program)

      Co-Chair: Katie Stebbins, MS – Tufts University Food & Nutrition Innovation Institute

    • 12:05 PM – 12:15 PM ET
      Presentation 1 - The Scientific Evolution of Bioactives in Human Health, Current Challenges, and the Path Ahead Illuminated by AI Driven Science (Sponsored Satellite Program)

      Speaker: Jan-Willem Van Klinken, MD, PhD, MS, FACN (he/him/his) – Brightseed

    • 12:15 PM – 12:25 PM ET
      Presentation 2 - The Scientific Evolution of Bioactives in Human Health, Current Challenges, and the Path Ahead Illuminated by AI Driven Science (Sponsored Satellite Program)

      Speaker: Christina Khoo, PhD (she/her/hers) – Ocean Spray

    • 12:25 PM – 12:35 PM ET
      Presentation 3 - The Scientific Evolution of Bioactives in Human Health, Current Challenges, and the Path Ahead Illuminated by AI Driven Science (Sponsored Satellite Program)

      Speaker: Mario G. Ferruzzi, PhD – University of Arkansas for Medical Sciences

    • 12:35 PM – 1:30 PM ET
      Panel Discussion - The Scientific Evolution of Bioactives in Human Health, Current Challenges, and the Path Ahead Illuminated by AI Driven Science (Sponsored Satellite Program)

      Chair: Katie Stebbins, MS – Tufts University Food & Nutrition Innovation Institute

      Co-Chair: Swati Kalgaonkar, PhD – Brightseed

      Speaker: Jan-Willem Van Klinken, MD, PhD, MS, FACN (he/him/his) – Brightseed

      Speaker: Christina Khoo, PhD (she/her/hers) – Ocean Spray

      Speaker: Mario G. Ferruzzi, PhD – University of Arkansas for Medical Sciences

      Panelist: Taylor C. Wallace, PhD (he/him/his) – Think Healthy Group, LLC / Friedman School of Nutrition Science and Policy, Tufts University

      Panelist: Janet A. Novotny, PhD (she/her/hers) – United States Department of Agriculture

      Panelist: Connie M. Weaver, PhD (she/her/hers) – San Diego State University