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Topical Area: Dietary Patterns

Dietary Patterns (Poster Session)

(P14-053-23) The Sulfur Microbial Diet and Increased Risk of Obesity: Findings From a Population-Based Prospective Cohort Study

Sunday, July 23, 2023

12:45 PM – 1:45 PM ET

Location: Poster Board 53

Presenting Author(s)

Xiaohui Liu, Graduate Student

Nutrition
Zhejiang University
Hangzhou, Zhejiang, China (People's Republic)

Co-Author(s)

JJ

Jingjing Jiao, Professor

Zhejiang University
Hang zhou, Zhejiang, China (People's Republic)
PZ

Pan Zhuang, Doctor

PhD student
Zhejiang University
Hang zhou, Zhejiang, China (People's Republic)

Disclosure(s):

Xiaohui Liu, Graduate Student: No relevant financial relationship(s) with ineligible companies to disclose.

Pan Zhuang, Doctor: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: Gut-produced hydrogen sulfide (H₂S) has been associated with increased gut permeability and inflammation, which may be related to higher obesity risk. We investigated the association of sulfur microbial diet, a dietary index associated with 43 sulfur-metabolizing bacteria, with the incident obesity and whether the relationship was modified by the genetic predisposition to obesity.

Methods: We included 27,429 participants with available body mass index (BMI) data from the UK Biobank. The sulfur microbial diet score was assessed using the 24-hour dietary assessment method. Obesity and abdominal obesity were defined according to the World Health Organization criteria. Body fat percentage was assessed using a body composition analyzer. The genetic risk score (GRS) was calculated by 940 BMI-related variants.

Results: We documented 1472 and 2893 cases of obesity and abdominal obesity during a mean follow-up of 8.1 years. After multivariable-adjustment, the sulfur microbial diet score was positively associated with obesity (HR_Q4vsQ1=1.63; 95% CI=1.40–1.89, P-trend =0.001) and abdominal obesity risk (HR_Q4vsQ1=1.17; 95% CI=1.05–1.30, P-trend =0.002). We also observed that increased sulfur microbial diet score was related to several adiposity indicators, including 5% increase in BMI, WC, and body fat percentage. Moreover, the sulfur microbial diet had no significant interactions with genetic risk on obesity incidence.

Conclusions: Our results emphasized the significance of avoiding sulfur microbial diet for obesity prevention across all levels of genetic risk.

Funding Sources: This research was supported by the Fundamental Research Funds for the Central Universities of China and the National Natural Science Foundation of China.