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Cellular and Physiological Nutrition/Metabolism

Clinical and Translational Nutrition
Session Type: Symposium

Metabolic Adaptation and Increased Drive to Eat as Drivers of Weight Regain in Individuals with Obesity. Myth or Reality? An Exercise in Adversarial Collaboration

Tuesday, July 25, 2023
10:00 AM – 11:30 AM ET
Location: Grand Ballroom

CPE for RDs

Learning Objectives

At the end of this activity, learners will be able to:
  • Describe the concept of Adversarial Collaboration
  • Define the proposed concept of metabolic adaptation
  • Explain the areas of controversies surrounding metabolic adaptation

      • Chair(s)

    • James Hill, PhD

      Professor and Director, Nutrition Obesity Research Center
      Department of Nutrition Sciences
      University of Alabama at Birmingham
      Birmingham, Alabama, United States

      Disclosure(s): General Mills: Advisory Committee/Board Member (Ongoing)
      McCormick Science Institute: Advisory Committee/Board Member (Ongoing)
      Shakabuku, LLC: Ownership Interest (Ongoing)

    • Drew Sayer, PhD (he/him/his)

      Assistant Professor
      Department of Family and Community Medicine
      The University of Alabama at Birmingham
      Birmingham, Alabama, United States

      Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

      • Speaker(s)

    • CM

      Catia Martins, Phd, RD (she/her/hers)

      Associate Professor
      Nutrition Sciences Research
      The University of Alabama at Birmingham
      Tuscaloosa, Alabama, United States

      Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

    • JK

      Jonathan Krakoff, MD

      Chief, Obesity and Diabetes Clinical Research Section
      Obesity and Diabetes Clinical Research Section
      NIDDK-Phoenix
      Phoenix, Arizona, United States

      Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

    Disclosure(s):
    James O. Hill, PhD: General Mills: Advisory Committee/Board Member (Ongoing)
    McCormick Science Institute: Advisory Committee/Board Member (Ongoing)
    Shakabuku, LLC: Ownership Interest (Ongoing)
    Drew Sayer, PhD: No relevant financial relationship(s) with ineligible companies to disclose.
    Catia Martins, Phd, RD: No relevant financial relationship(s) with ineligible companies to disclose.
    Jonathan Krakoff, MD: No relevant financial relationship(s) with ineligible companies to disclose.

    Weight regain remains the main challenge in obesity management, with 30-50% of the initial weight lost being regained within the first year and most individuals returning to, or above, their baseline weight within 5 years. Weight loss is followed by an increased drive to eat and reduced energy expenditure (EE), both suggested to drive weight regain. Metabolic adaptation, a reduction in EE below predicted values, is a physiological phenomenon that might contribute to resistance to weight loss and increase the risk of weight regain. However, the existence and clinical relevance of metabolic adaptation remain one of the most controversial issues in nutrition science.

    Meet our collaborators who each have differing views and have agreed to work together to untangle the controversy: Catia Martins, PhD, RD, Associate Professor, The University of Alabama at Birmingham and Jonathan Krakoff, MD, NIDDK-Phoenix, Arizona.

    At NUTRITION 2023, Dr. Martins will define what is known and not known about metabolic adaptation and she and Dr. Krakoff will present their views. They also will present their research plan to advance the science and understanding of this topic.

    Our collaborators will tap into the collective knowledge of the NUTRITION 2023 community by taking questions, listening to advice, and considering innovative ideas.

    Presentations:

    • 10:00 AM – 10:05 AM ET
      Introduction to the ASN – UAB NORC Adversarial Collaboration Project

      Chair: Drew Sayer, PhD (he/him/his) – The University of Alabama at Birmingham

    • 10:05 AM – 10:25 AM ET
      What Do We Know and Not Know About Metabolic Adaptation?

      Speaker: Catia Martins, Phd, RD (she/her/hers) – The University of Alabama at Birmingham

    • 10:25 AM – 10:40 AM ET
      Two Views: Part 1

      Speaker: Catia Martins, Phd, RD (she/her/hers) – The University of Alabama at Birmingham

    • 10:40 AM – 10:55 AM ET
      Two Views: Part 2

      Speaker: Jonathan Krakoff, MD – NIDDK-Phoenix

    • 10:55 AM – 11:10 AM ET
      The Plan to Unravel the Controversy

      Speaker: Catia Martins, Phd, RD (she/her/hers) – The University of Alabama at Birmingham

      Speaker: Jonathan Krakoff, MD – NIDDK-Phoenix

    • 11:10 AM – 11:30 AM ET
      Crowdsourced Perspectives

      Chair: James O. Hill, PhD – University of Alabama at Birmingham

      Chair: Drew Sayer, PhD (he/him/his) – The University of Alabama at Birmingham

      Speaker: Catia Martins, Phd, RD (she/her/hers) – The University of Alabama at Birmingham

      Speaker: Jonathan Krakoff, MD – NIDDK-Phoenix