Icon Legend

This session is not in your schedule.

This session is in your schedule. Click again to remove it.

Session: Diet and Cancer: Focus on Breast Cancer Prevention and Survivorship (Oral 25)

(OR25-06-23) Dietary Patterns Related to Biological Mechanisms and Survival After Breast Cancer Diagnosis: Results From a Cohort Study

Tuesday, July 25, 2023

10:48 AM – 11:00 AM ET

Location: Constitution B

Presenting Author(s)

Carlota Castro-Espin, MSc, PhD student

PhD student
Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL)
Sant Feliu de Llobregat, Catalonia, Spain

Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

Co-Author(s)

Carlota Castro Espin, MSc (she/her/hers)

PhD Student
Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL)
Sant Feliu de Llobregat, Catalonia, Spain
CB

Catalina Bonet, MSc

Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL)
Hospitalet de Llobregat, Catalonia, Spain
CM

Crous-Bou Marta, PhD (she/her/hers)

Principal Investigator
Catalan Institute of Oncology (ICO)-Bellvitge Biomedical Research Center (IDIBELL)
Barcelona, Catalonia, Spain
LD

Laure Dossus, PhD

International Agency for Cancer Research (IARC)
Elio Riboli, Professor

Professor, Chair in Cancer Epidemiology and Prevention
School of Public Health, Faculty of Medicine, Imperial College London
London, England, United Kingdom
Carlota Castro-Espin, MSc, PhD student

PhD student
Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL)
Sant Feliu de Llobregat, Catalonia, Spain
AA

Antonio Agudo, MD, PhD

Head, Unit of Nutrition and Cancer
Catalan Institute of Oncology (ICO)-Bellvitge Biomedical Research Center (IDIBELL)
Hospitalet de Llobregat, Catalonia, Spain

Disclosure(s):

Carlota Castro-Espin, MSc, PhD student: No relevant financial relationship(s) with ineligible companies to disclose.

Carlota Castro Espin, MSc: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: We aimed to examine associations between pre-diagnosis dietary patterns related to biological mechanisms underlying breast carcinogenesis, including inflammatory, insulin and estrogenic pathways, in relation to breast cancer (BC) survival.

Methods: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and estrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adjusted Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality.

Results: We included 13270 BC cases with a mean follow-up of 8.6 years since diagnosis, with 2340 total deaths including 1475 from BC. High DRRD score was associated with lower risk of overall mortality (HR_SD 0.92 95%CI 0.87-0.96); adherence to pro-inflammatory diets was borderline associated with 6% higher risk of mortality (95%CI 1.00-1.12). Women with anti-diabetic and anti-inflammatory diets (high DRRD and low ISD) had 17% lower risk of overall mortality. No significant association with the ERDP was observed. No dietary pattern was associated with BC-specific mortality.

Conclusions: Higher adherence to an anti-diabetic and anti-inflammatory diet before diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.

Funding Sources: C Castro-Espin is funded by Instituto de Salud Carlos III - Grant FI19/00197 (Co-funded by European Social Fund. ESF investing in your future)

This work has been carried out within the framework of a project supported by the following grants: Instituto de Salud Carlos III through the project PI18/00190 (Co-funded by European Regional Development Fund. ERDF, a way to build Europe). PRYES211366AGUD funded by the Scientific Foundation of the AECC.

The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which receives inflastructure support from the NIHR Imperial Biomedical Research Centre (BCR).

We thank CERCA Programme / Generalitat de Catalunya for institutional support.