(P08-008-23) Prediction of Dysglycemia Through Easily Accessible Clinical, Anthropometric, and Biochemical Measurements

Objectives: The aim of the study was to assess dysglycemia and prognostic assessment of body composition capacity, biochemical and clinical parameters as a predictor of abnormal 2-hour OGTT.

Methods: This cross-sectional study was conducted in 381 subjects with overweight or obesity. Participants underwent a physical examination in which their anthropometric measurements were obtained, and a blood sample was taken for biochemical and hormonal analysis. All patients underwent a 75-g OGTT after 8-h of fasting, and the levels of glucose and insulin were measured. The results were compared statistically by dividing the participants 2-h-postprandial glucose (PG) into normoglycemia (NGT) < 140 mg/dL, prediabetes 140 to 199 md/dL and T2D ≥ 200 mg/dL.

Results: In 381 overweight and obese subjects with OGTT results available, 220 belonged to the NGT group, 131 to the prediabetes group, and 30 to the diabetes group. As expected, fasting glucose, 1-h-PG, 2-h-PG, hemoglobin glycosylated (A1c) and QUICKI index were significantly higher as the stages of glycemic dysregulation progressed. Interestingly, 53.4% of the NGT group had a monophasic type of curve in the OGTT and a QUICKI index of 0.32. A statistically significant positive correlations were obtained between 2 h-PG with age, glucose, C-reactive protein (CRP), A1c, HOMA-IR index and QUICKI index in the NGT group. Meanwhile, in the prediabetes group positive correlations were obtained between 2 h-PG with age, systolic blood pressure, diastolic blood pressure, glucose, and HDL cholesterol. No correlations were obtained in the diabetes group. Subsequently, predictive models of 2-h-PG were performed, obtaining 4 models. The best model obtained a coefficient of determination of 0.747 (p = 0.001) with the variables A1c, CRP, body fat mass, and total cholesterol.

Conclusions: The use of A1c, CRP, body fat mass, and total cholesterol in a model might predict 2-h-PG without the need of a 2-h OGTT.

Funding Sources: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán department ofNutrition Physiology. Universidad Nacional Autónoma de México, postgraduate course Biomedical Sciences.