(P11-001-23) Correlation Between Blood Manganese Levels and Enzymatic Markers of Tissue Damage - Effect of Zinc Status

Objectives: This study was set out to investigate: 1) whether blood manganese levels correlate with enzymatic markers of tissue damage, and 2) whether zinc status influences the effect of blood manganese on enzymatic markers of tissue damage.

Methods: The study used the (NHANES) dataset to investigate the effect of manganese levels on the levels of markers of liver and other tissue damage in individuals aged 25 to 80 years. The effect of different levels of zinc intake and serum zinc was evaluated. The dataset was cleaned based on NHANES analytic guidelines, and descriptive statistics were provided. The data were analyzed using a general complex sample regression analysis. To reveal the effect of zinc intake and serum zinc intake, the zinc intake categorical variable and the serum zinc categorical variable were included as factors to identify the interaction effect of zinc intake and serum zinc on blood manganese toxicity.

Results: Analysis of NHANES data reveals that blood manganese levels are directly and significantly (p < 0.05) associated with the enzymatic markers of tissue damage: alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). In addition, our results indicate that the correlation between blood manganese and ALP was blunted in individuals with adequate zinc intake.

Conclusions: The study found a complex relationship between blood manganese, enzymatic markers of tissue damage, and zinc status. The results suggest that adequate zinc intake could attenuate manganese toxicity. However, further research is required to comprehend these complex interactions and their impact on human health.

Funding Sources: Florida International University