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Topical Area: Vitamins and Minerals

Vitamins and Minerals (Poster Session)

(P11-012-23) Vitamin D Status and Risk of Heart Failure among Individuals With Type 2 Diabetes: Observational and Mendelian Randomization Studies

Saturday, July 22, 2023
12:00 PM – 1:00 PM ET
Location: Poster Board 235

    Presenting Author(s)

  • XC

    Xue Chen, MBBS

    student
    Huazhong University of Science and Technology
    Wuhan, Hubei, China (People's Republic)

    • Co-Author(s)

  • ZW

    Zhenzhen Wan

    Huazhong University of Science and Technology

  • TG

    Tingting Geng

    Huazhong University of Science and Technology

  • KZ

    Kai Zhu

    Huazhong University of Science and Technology

  • RL

    Rui Li

    Huazhong University of Science and Technology, Tongji Medical College, School of Public Health

  • QL

    Qi Lu, NA

    Huazhong University of Science and Technology, Tongji Medical College, School of Public Health
    Wuhan, Hubei, China (People's Republic)

  • XL

    Xiaoyu Lin

    Huazhong University of Science and Technology

  • SL

    Sen Liu

    Huazhong University of Science and Technology

  • YO

    Yunjing Ou

    Huazhong University of Science and Technology

  • KY

    Kun Yang

    Guoyao Dongfeng General Hospital, Hubei University of Medicine

  • AP

    An Pan, PhD

    Professor
    Huazhong University of Science and Technology, Tongji Medical College, School of Public Health
    Wuhan, Hubei, China (People's Republic)

  • JM

    JoAnn E. Manson

    Harvard T.H. Chan School of Public Health

  • GL

    Gang Liu

    Huazhong University of Science and Technology, Tongji Medical College, School of Public Health

Disclosure(s):
Xue Chen, MBBS: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: Recent studies have suggested that high intakes of vitamin D may not confer greater cardiovascular benefit than moderate intakes, but evidence is limited for heart failure (HF) outcomes and for people with type 2 diabetes (T2D), among whom vitamin D insufficiency or deficiency is particularly common. This study aimed to investigate the associations of serum 25-hydroxyvitamin D [25(OH)D] with HF risk among individuals with T2D, in observational and Mendelian randomization (MR) frameworks.

Methods: Observational analyses were performed among 15,226 participants aged 37-73 with T2D from the UK Biobank. HF incidence was ascertained through electronic health records. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). MR analyses were conducted among 11,260 unrelated T2D patients. A weighted genetic risk score (GRS) for genetically predicted 25(OH)D concentration was instrumented using 62 confirmed genome-wide significant variants.

Results: The mean ± standard deviation of serum 25(OH)D concentration was 43.4 ± 20.4 nmol/L, and 65.7% participants had vitamin D less than 50 nmol/L. During a median follow-up of 11.1 years, 836 incident HF events occurred. Serum 25(OH)D was nonlinearly and inversely associated with HF and the decreasing risk tended to plateau at around 50 nmol/L. Comparing those with 25(OH)D < 25 nmol/L, the multivariable-adjusted HR (95% CI) for participants with 25(OH)D of 50.0-74.9 nmol/L was 0.66 (0.53, 0.82) and was similar for 25(OH)D >75 nmol/L. No effect modification of VDR polymorphisms was observed. In MR analysis, higher genetically predicted 25(OH)D was significantly associated with lower HF risk among (HR: 0.64, 95% CI: 0.40, 0.99; P</em>=0.05) at borderline significance.

Conclusions: Serum 25(OH)D was nonlinearly and inversely associated with HF risk among T2D population and the MR analysis suggested a potential causal relationship. These findings indicate a potential role of maintaining adequate vitamin D status in the prevention of HF among individuals with T2D.

Funding Sources: National Nature Science Foundation of China;
Hubei Province Science Fund for Distinguished Young Scholars;
Fundamental Research Funds for the Central Universities.