(P11-038-23) The Micronutrients and Supplements Related to Cardiovascular Disease, Cognitive Impairment Disease, and Four Cancers: Using Network Analysis With PubMed Abstracts

Objectives: This study was conducted to identify the notable micronutrients and supplements mentioned in abstracts of articles about cardiovascular disease, cognitive impairment disease, and four cancers using the big data analysis method.

Methods: Each research abstracts on micronutrients and supplements related to cardiovascular disease (myocardial infarction, hypertension, diabetes mellitus, hyperlipidemia, metabolic syndrome), cognitive impairment disease (Alzheimer’s disease and mild cognitive impairment), and four cancers (breast, prostate, lung, colon) were extracted from MEDLINE using PubMed on December 2019. Text mining was performed to extract nutrient or supplement-related words from collected abstracts. Network analysis was performed using top frequency and centrality of micronutrients or supplements keywords in each disease.

Results: As a result of analysis, the major micronutrients or supplements in myocardial infarction(1,905 abstracts), hypertension(1,900s), diabetes mellitus(2,684s), hyperlipidemia(1,338s), and metabolic syndrome(953s) were; calcium, vitamin B12, vitamin D, zinc, magnesium, and selenium. Omega 3, vitamin B12, and folate were top-ranking micronutrients in Alzheimer's disease (495s) and mild cognitive impairment (604s). In 1,547 abstracts of breast and 1,176s of prostate cancer, major micronutrients and supplements were selenium, soybean, and vitamin D. Vitamin A and E were major micronutrients in lung cancer (111s), while calcium and iron were in colon cancer (1,048s).

Conclusions: Calcium, vitamin B12, and selenium were common major micronutrients related to cardiovascular disease, cognitive impairment disease, and four cancers by big data analysis of abstracts related to this disorder.

Funding Sources: The authors state no funding is involved.