Skip to main content
NUTRITION 2023 Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Back

Topical Area: Nutritional Epidemiology

Nutritional Epidemiology (I) (Poster Session)

(P19-035-23) The Relationships of Dietary and Circulating Total Branched-Chain Amino Acids With Type 2 Diabetes

Sunday, July 23, 2023
11:45 AM – 12:45 PM ET
Location: Poster Board 132

    Presenting Author(s)

  • AO

    Akinkunmi Paul Okekunle, PhD

    Assistant Professor
    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

    • Co-Author(s)

  • HL

    Heejin Lee (she/her/hers)

    Student
    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • SP

    Sherlyn Mae P. Provido, PhD

    Graduate student
    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • GC

    Grace H. Chung, PhD

    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • SH

    Sangmo Hong, PhD

    Hanyang University Guri Hospital, Hanyang University College of Medicine
    Guri, Seoul-t'ukpyolsi, Republic of Korea

  • SY

    Sung Hoon Yu, PhD

    Hanyang University Guri Hospital, Hanyang University College of Medicine
    Guri, Seoul-t'ukpyolsi, Republic of Korea

  • CL

    Chang Beom Lee, PhD

    Hanyang University Guri Hospital, Hanyang University College of Medicine
    Guri, Seoul-t'ukpyolsi, Republic of Korea

  • JL

    Jung Eun Lee, ScD

    Associate Professor
    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

Disclosure(s):
Akinkunmi Paul Okekunle, PhD: No relevant financial relationship(s) with ineligible companies to disclose.
Heejin Lee: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: This cross-sectional study evaluated the association of dietary and circulating total branched-chain amino acids (tBCAA) and their joint associations with type 2 diabetes (T2D) among Filipino women in Korea.

Methods: A total of 555 Filipino women were included, and 39 women had T2D. Energy-adjusted dietary tBCAA intakes were assessed using the 24-hour recalls, and serum tBCAA profiles were profiled using high-throughput proton–nuclear magnetic resonance metabolomics in the Filipino women's diet and health study. Dietary and serum tBCAA were ranked by quartiles. Dietary and serum tBCAA were dichotomized by median ('low' - < median and 'high' - ≥median) and combined into four joint categories to examine the joint association. T2D was defined as one of the following conditions; a previous diagnosis of diabetes, current use of glucose-lowering medications, fasting blood glucose ≥ 126mg/dl, or glycated haemoglobin ≥ 6.5%. Multivariable-adjusted logistic regression was used to estimate the odds ratio (OR)s and 95% confidence intervals (CI)s of T2D prevalence.

Results: Energy-adjusted dietary tBCAA intakes were not associated with T2D prevalence, but higher serum tBCAA profiles were associated with higher T2D prevalence. The ORs (95% CIs) for subsequent quartiles of serum tBCAA levels were 1.16 (0.26, 5.15), 1.92 (0.51, 7.20), and 5.78 (1.69, 19.80), compared to the first quartile (P for trend < 0.001). When we examined the joint association of dietary and circulating tBCAAs, ORs (95% CIs) for T2D prevalence were 3.79 (0.95, 15.10) for low dietary and high serum tBCAA, 1.96 (0.41, 9.35) for high dietary and low serum tBCAA and 6.49 (1.61, 26.09) for high dietary and high serum tBCAA, compared to low dietary and low serum tBCAA. However, the interaction was not statistically significant.

Conclusions: We found that higher serum tBCAA levels were associated with higher T2D prevalence among Filipino women in Korea.

Funding Sources: Seoul National University Asia Center; National Research Foundation of Korea; the Hanmi Pharmaceutical Co., Ltd; Chong Kun Dang Pharm; Yuhan Corporation.