(P19-032-23) Associations of Furan Fatty Acid Metabolite CMPF With Incident Type 2 Diabetes and Chronic Kidney Disease: A Longitudinal Population-Based Cohort Study

Objectives: Furan fatty acid metabolite 3-carboxy-4-methyl-5- propyl-2-furanpropanoic acid (CMPF) is a strong biomarker of fish and n-3 polyunsaturated fatty acid (PUFA) intake. The relationship of CMPF with human health has been controversial, especially for type 2 diabetes and chronic kidney disease. We aimed to examine the association of CMPF with incident type 2 diabetes and chronic kidney disease.

Methods: In the Guangzhou Nutrition and Health study, with an approximately nine years’ follow-up, we used a multivariable-adjusted Poisson regression model to investigate the association of baseline serum CMPF with the incidence of type 2 diabetes and chronic kidney disease among 1,470 (170 incident cases) and 1,436 participants (112 incident cases), respectively. We also examined the association of serial measures of serum CMPF with glycemic and renal function biomarkers. Then, a mediation analysis was performed to examine the contribution of CMPF in the association between marine n-3 fatty acids and the risk of type 2 diabetes or chronic kidney disease.

Results: Per standard deviation (SD) change in the baseline serum CMPF was associated with a 18% lower risk of type 2 diabetes (relative risk 0.82, 95% confidence interval (CI) 0.68-0.99), but not associated with chronic kidney disease (relative risk 0.95, 95% CI 0.77-1.16). Correlation analyses of CMPF with glycemic and renal function biomarkers showed similar results. The mediation analysis suggested that serum CMPF contributed to the inverse association between marine n-3 PUFAs and incident type 2 diabetes (proportion mediated 37%, p-mediation=0.022).

Conclusions: Serum CMPF was associated with a lower risk of type 2 diabetes, but not chronic kidney disease. This study suggests that CMPF may be a functional metabolite underlying the protective relationship between marine n-3 PUFAs and type 2 diabetes.

Funding Sources: This study was funded by the National Key R&D Program of China, the National Natural Science Foundation of China, the China Postdoctoral Science Foundation, the Research Program of Westlake Laboratory of Life Sciences and Biomedicine and the 5010 Program for Clinical Researches of the Sun Yat-sen University.