(P25-005-23) Effect of Annona muricata (Soursop) Leaf Extract on Hyperlipidemia and Hyperglycemia

Objectives: The use of materials of plant origin have been observed to be a cost-effective strategy in managing hyperlipidemia and hyperglycemia. The objective of the study was to evaluate the effect of Annona muricata (soursop) leaf extract on hyperlipidemia and hyperglycemia.

Methods: Experimental design was adapted for the study, where 20 adult male rats were randomly assigned to 3 treatment groups and 1 non-treatment group, with 5 rats in each group. Standard method was used to process the vegetable (soursop leaves) into aqueous extract. One gram each of the extracts was dissolved in 10 mL of distilled water in order to prepare a stock of 100 mgmL^-1. Hyperglycemia induction was done using alloxan. Treatment lasted for 21days. Standard method was used to determine blood glucose and lipid profiles of the rats. Sample-paired t-test (P < 0.05) was used to analyze the effect while percentage difference was calculated.

Results: After 21days treatment with aqueous extracts of Annona muricata leaves at 400mgkg^-1 and 800mgkg^-1 body weight (BW), blood glucose levels of the rats declined by 66.40% and 51.60%, respectively, compared to 61.19% decline after treatment with antidiabetic standard drug at 500µg (SD500). There was a significant difference (P < 0.05) between the mean initial and final cholesterol levels of the rats treated with Annona muricata leaves both at 400mgkg^-1 and 800mgkg^-1 BW and SD500µg with 35.4%, 42.9% and 39.4% decrease, respectively. There was no significant difference (P > 0.05) between the mean initial and final High Density Lipoprotein (HDL) levels of the rats treated with Annona muricata at 800mgkg^-1 BW, however, a 26.9% rise in their HDL levels was observed.

Conclusions: The study confirmed the potentials of Annona muricata leaf in management of hyperlipidemia and hyperglycemia. There is need to carry out a similar study in humans.

Funding Sources: Self funded