Topical Area: Neuroscience/Nutrition and the Brain
Neuroscience/Nutrition and the Brain (Poster Session)
(P27-031-23) Translational Investigation of the Influence of Dietary Botanical Supplements on Biological and Behavioral Resilience From the Preclinical to Clinical
Objectives: IIn this presentation I review a cohesive program of integrated approaches that comprehensively address the objectives In particular, the principal objective of our Consortium for Advancing Research on Botanicals and other natural products (CARBON ) is to provide valuable insight, through translational investigation that may inform a future clinical trial to provide resilience against stress-induced psychological impairment.
Methods: Our CARBON identifies biological targets in microglia, interneurons, and blood-brain barrier cells influenced by polyphenol metabolites by state-of-the-art cell-specific RNA-sequencing and imaging techniques. In addition in clinical studies we will assess the clinical properties of complex polyphenolic preparation and through pharmacokinetic and steady-state profiles we will define bioavailable metabolites found in human plasma, and confirm the presence of metabolites that exert biological effects against proinflammatory cytokines We will use multivariate adaptive regression splines model to identify specific metabolites or combinations of the polyphenolic preparation to identify pro-inflammatory markers of biological resilience in response to treatment assessing resilience in human Trier Social Stress.
Results: Our CARBON identifies biological targets in microglia, interneurons, and blood-brain barrier cells influenced by polyphenol metabolites by state-of-the-art cell-specific RNA-sequencing and imaging techniques. In addition in clinical studies we will assess the clinical properties of complex polyphenolic preparation and through pharmacokinetic and steady-state profiles we will define bioavailable metabolites found in human plasma. We will use the multivariate adaptive regression splines model to identify specific metabolites or combinations of the polyphenolic preparation to identify anti-inflammatory markers of biological resilience in response to treatment assessing resilience in human Trier Social Stress.
Conclusions: Our studies will provide information of the mechanism of action and the clinical properties of a complex polyphenolic preparation and its metabolites needed to optimize design of a future clinical trial to test resiliency afforded by polyphenols in response to stress in clinical settings.
