Sookyeong Hong, bachelor: No relevant financial relationship(s) with ineligible companies to disclose.
Objectives: Blackcurrant (Ribes nigrum L.) is known to contain high-level of phytochemicals such as polyphenols, which can ameliorate lipid accumulation due to its antioxidant effect. This research evaluated the hypolipidemic effect of blackcurrant extract on rats fed with high-fat-high-fructose diet.
Methods: Thirty two 6-week-old male SD rats were randomly allocated into 2 groups and were fed normal diet (ND) (n=9) and the high-fat-high-fructose diet group (HF) (n=23) for 14 weeks. Oral administration of blackcurrant extract with different doses of 0 mg/kg bw/day (HF) (n=9), 150 mg/kg bw/day (LC) (n=7), and 250 mg/kg bw/day (HC) (n=7) were given by gavage to HF groups from week 8. Lipid profiles, such as triglyceride(TG), total cholesterol(TC), and high density lipoprotein-cholesterol(HDL-C) were assessed through ELISA kit. Atherogenic index(AI), high density lipoprotein-cholesterol(LDL-C), and cardiovascular risk ratio(CRR) were also calculated.
Results: In serum TG, TC, and LDL-C, both LC group and HC group showed significant reduction compared to HF group. HDL-C level of LC group and HC group were higher than HF group but did not reach statistical significance. Both AI and CRR of LC group was significantly lower than HC group, and those of both LC and HC group were significantly lower than HF group.
Conclusions: Overall, these data suggest efficacy of Blackcurrant extract in ameliorating lipid profiles, providing evidence for its potential in preventing diseases such as NAFLD, metabolic syndrome, and other cardiovascular disease via ameliorating lipid accumulation.
Funding Sources: This study was supported by the BK-21 FOUR (Fostering Outstanding Universities for Research) funded by Ministry of Education (MOE) of Korea and National Research Foundation (NRF) of Korea.
