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Topical Area: Nutritional Epidemiology

Nutritional Epidemiology (II) (Poster Session)

(P29-007-23) Associations of Serum Lipid-Soluble Micronutrients With Hepatic Steatosis Among Adults in the United States

Monday, July 24, 2023

12:45 PM – 1:45 PM ET

Location: Poster Board 134

Presenting Author(s)

Weiwen Chai, PhD

Associate Professor
University of Nebraska-Lincoln
Lincoln, Nebraska, United States

Co-Author(s)

MT

Menghua Tao, PhD (she/her/hers)

Assistant Scientist
Henry Ford Health System
Detroit, Michigan, United States

Disclosure(s):

Weiwen Chai, PhD: No relevant financial relationship(s) with ineligible companies to disclose.

Menghua Tao, PhD: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: Research suggests lipid-soluble micronutrients may be beneficial to chronic disease treatment and prevention. This study examined associations of serum lipid-soluble micronutrients (α- and γ-tocopherols, 25-hydroxy-vitamin D [25(OH)D], retinol, and carotenoids) and hepatic steatosis among adults in the United States utilizing the 2017-2018 National Health and Nutrition Examination Survey.

Methods: The analysis included 4779 adults aged ≥20 years who completed the transient elastography examination. A threshold value of 302 dB/m was selected to identify participants with steatosis (S > S1, 5% steatosis). Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using logistic regressions adjusting for relevant covariates.

Results: The age-adjusted prevalence of steatosis was 28.0%. Higher serum α-tocopherol (highest vs. lowest quartile: OR=1.63, 95%CI=1.07-2.48, P_trend=0.02) and γ-tocopherol (highest vs. lowest quartile: OR=2.42, 95%CI=1.80-3.24, P_trend < 0.0001) levels were associated with increased odds of steatosis. Higher serum 25(OH)D levels were associated with reduced odds of steatosis (highest vs. lowest quartile: OR=0.53, 95%CI=0.38-0.75, P_trend=0.002). Inverse associations with steatosis were also observed for carotenoids such as α-carotene (P_trend < 0.0001), β-carotene (P_trend < 0.0001), and α-cryptoxanthin (P_trend=0.025) in the serum.

Conclusions: Our results suggest potential protective associations of serum lipid-soluble micronutrients such as 25(OH)D and carotenoids with steatosis. The positive associations between tocopherols and steatosis may indicate inflammation associated with steatosis as it was reported γ-tocopherol rises in response to inflammation.

Funding Sources: N/A