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Topical Area: Obesity

Obesity (Poster Session)

(P31-031-23) CAP-LMT (Compatibility-Based Allocation-Focused Progress Monitoring Lifestyle Modification Treatment)

Monday, July 24, 2023
12:45 PM – 1:45 PM ET
Location: Poster Board 253
Disclosure(s):
Gaurav Mahendra Kudchadkar, MBBS: No relevant financial relationship(s) with ineligible companies to disclose.
Nikhil V. Dhurandhar, LCEH, MS. PhD, FTOS: Borealis Foods: Grant/Research Support (Ongoing)
Indiana University Foundation: Grant/Research Support (Ongoing)
Insparin Therapeutics: Grant/Research Support (Ongoing); Ownership Interest (Ongoing)
International Egg Commission: Advisory Committee/Board Member (Ongoing)
Medifast: Advisory Committee/Board Member (Ongoing)
Metabologix/ Obthera: Consultant (Ongoing)
National Cattleman's Beef Association: Grant/Research Support (Terminated)
Novo Nordisk: Grant/Research Support (Terminated)
Springer Nature: Advisory Committee/Board Member (Ongoing)


Objectives: CAP-LMT is a structured obesity management approach, successfully used in the Indian subcontinent in over 200,000 individuals over the past 60 years. A study of 1117 patients using the approach showed about 9 - 10% weight loss in individuals who completed 15 weeks program (Dhurandhar & Kulkarni, 1993 https://doi.org/10.3109/09637489309017425). The weight loss diet used in CAP-LMT follows adequate protein, moderate carbohydrate and lower fat content as the central guideline. However, the diet plan is highly individualized, based on numerous considerations including personal and family history, lifestyle, likes and dislikes, occupational circumstances, family environment around food selection and cooking practices. Recommendations about specific food items for daily meals, quantities and recipes, are provided. The main focus is on developing a personalized diet that is easier to follow for an individual and thereby increasing compliance. Our objective was to implement this method for the first time in the United States.

Methods: CAP-LMT approach was offered for weight management on a fee for service basis. Weight loss was determined as an initial step in evaluating efficacy of CAP-LMT in this population. Patients were evaluated carefully during their initial visit, had bio-electrical impedance analysis for body composition, indirect calorimetry for resting metabolic requirement determination, blood chemistry analysis, and a detailed interview. Next, their diet was planned and recommended based on CAP-LMT guidelines.

Results: Of the 14 individuals starting the program, 11 individuals completed at least 12 weeks of treatment (3 males, 8 females). Compared to baseline, the 12-wk completers lost 5.26% body weight and 11.27% fat mass in 12 wks. Six individuals (55%) lost >5% body weight. Systolic BP reduced from 120 to 114 mmHg (p < 0.07) and the diastolic BP reduced from 85 to 74 mmHg (p < 0.003).

Conclusions: This is the first efficacy evaluation of CAP-LMT in the USA. The reduction in weight and BP indicates good acceptability and compliance and show similar or better results compared to many behavioral weight loss studies in the USA. The results strongly support continued application of the CAP-LMT approach in various subgroups for further testing its adaptability.

Funding Sources: None