(P31-043-23) Normal Diet vs. High Fat Diet – Comparative Study: Pro-Lipolytic and Anti-Obese Effects of Cinnamon Extracts Dietary Supplementation in C57BL/6J Male Mice Model
Joohee Oh: No relevant financial relationship(s) with ineligible companies to disclose.
Objectives: Cinnamon is a common spice that has been used for its beneficial effects for thousands of years. Recently, many studies have been conducted on its potential beneficial effects on blood sugar control, heart disease, and inflammation, but little has been done on obesity. The aim of this study was to determine and compare the pro-lipolytic and anti-obese effects of cinnamon extracts dietary supplementation in C57BL/6J male mice model between normal diet and high fat diet.
Methods: The 6-week-old male C57BL/6J mice were randomized into 4 groups (n=10 for each group) after one week of adaptation period: Normal diet group (ND), normal diet with 1% Cinnamon extracts group (NC), high-fat diet group (HF), and high-fat-diet with 1% cinnamon extracts group (HC).
Results: After 14 weeks of each diet supplementation, common lipolysis and anti-obese indicators, triglyceride(TG) and total cholesterol(TC) in liver, AMP-activated protein kinase (AMPK) and Carnitine palmitoyltransferase I (CPT-1) in hepatic protein expression, and size of the adipose tissue in abdominal fat were measured. Levels of TG (p=0.005), and TC (p < 0.05) in liver tissue significantly decreased in HC compared to HF, but no significant differences were shown between ND and NC. Protein expression of AMPK in the liver showed significant increase in HC compared to HF group(p < 0.05) but no significant changes in the normal diet group. Protein expression of CPT-1 in the liver showed no difference in ND and NC but increased in HC than HF group. The size of adipose tissue area in abdominal fat, ND and NC showed the lowest range of the size, and in HC showed significantly decreased size of adipose tissue area than HF group (p < 0.001).
Conclusions: This study demonstrates that dietary cinnamon extracts supplementation can improve pro-lipolytic and anti-obese indicators such as TG, TC, AMPK and CPT-1 and can reduce the size of adipose tissue in high-fat diet induced mice model.
Funding Sources: This study was supported by the BK21 FOUR(Fostering Outstanding Universities for Research) funded by the Ministry of Education(MOE, Korea) and National Research Foundation of Korea(NRF) and Sookmyung Women’s University.
